Polyps in the colon are growths that may be benign (not cancerous) or pre-cancerous (may develop into cancer if not removed). Most colon polyps are discovered during routine screening tests such as a sigmoidoscopy or a fecal occult blood test (test for blood in the stool). Polyps that are likely to become cancerous should be removed. Some can be removed safely during a colonoscopy by colonoscopic polypectomy. We perform a new, non-surgical endoscopic technique known as Endoscopic Mucosal Resection (EMR) for removing large colon polyps and pre-cancerous flat dysplastic lesions. This procedure also is effective in the treatment of lesions in other parts of the gastrointestinal tract such as the esophagus, stomach and duodenum.